463-110 |Transcranial Color-Coded Doppler Cerebral Hemodynamics Following Aerobic Exercise Training: Outcomes from a Pilot Randomized Clinical Trial-Transcranial Color-Coded Doppler Cerebral Hemodynamics Following Aerobic Exercise Training: Outcomes from a Pilot Randomized Clinical Trial

Transcranial Color-Coded Doppler Cerebral Hemodynamics Following Aerobic Exercise Training: Outcomes from a Pilot Randomized Clinical Trial

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This study investigated the effects of exercise training on cerebral blood flow in middle-aged sedentary adults with a family history of Alzheimer's disease (AD). The researchers used transcranial color-coded Doppler (TCCD) to measure mean flow velocity (MFV) and pulsatility index (PI) in the middle cerebral arteries. Participants were randomized into an enhanced physical activity (EPA) exercise intervention group or a usual physical activity (UPA) control group. The exercise intervention consisted of supervised aerobic exercise training for 26 weeks. The results showed that there were no significant changes in MFV or PI in either the UPA or EPA groups between baseline and 26 weeks. There was also no evidence of an association between changes in cardiorespiratory fitness (VO2peak) and changes in MFV or PI. However, participants in the EPA group significantly increased their VO2peak compared to the UPA group. The study suggests that the exercise intervention did not lead to significant changes in cerebral hemodynamics, but future studies with larger cohorts and personalized exercise programs are needed to better understand the effects of exercise on cerebrovascular health in individuals at risk of AD.

Keywords

exercise training

cerebral blood flow

middle-aged sedentary adults

Alzheimer's disease

transcranial color-coded Doppler

mean flow velocity

pulsatility index

enhanced physical activity

usual physical activity

cardiorespiratory fitness